Main Congress Day 2

07:30 – 08:20

Laguna Ballroom

Young InSiGHT Breakfast Session

Chairs: 

Benjamin Zare, United Kingdom

Amalia Nanciu, Germany

Noah Helderman, Netherlands

Albatross & Birdie

ClinGen Vcep Breakout Session

Chairs: 

Marc Greenblatt, United States

Sharon Plon, United States

Eagle Boardroom

Genetic Counsellors’ Roundtable

Chairs: 

Manasa Karthikeyan, Singapore

Brandie Leach, United States

Marie Met-Domestici, Switzerland

Time

Laguna Ballroom

08:30 – 10:10

Session 3: Genetics and Molecular Insights in Hereditary Gastrointestinal Tumours

Chairs: Jean Christophe Saurin, France | Gloria Chan, Singapore

08:30 – 08:50

Tracing Cancer Evolution in Hereditary Gastrointestinal Tumours

Daniel Buchanan, Australia

08:50 – 09:10

Novel Genetic Drivers in Familial Colorectal Cancer

Laura Valle, Spain

09:10 – 10:10

Abstract Presentations 3

Chairs: Gabriel Capellá, Spain | Grolmusz Vince Kornel, United States [Y-InSiGHT]

Somatic CTNNB1 mutations as a positive predictor of Lynch syndrome

Aysel Ahadova, Germany

Inflammasome-related gene variant predisposing to familial colorectal carcinoma

Taina T Nieminen, Finland

Immune infiltration in Lynch syndrome colorectal cancer is linked to diagnostic context, not MMR gene defect

Noah Cornelis Helderman, Netherlands

Peripheral immunophenotyping reveals cancer-related alterations in Lynch syndrome

István Kelemen, Hungary

Remodeling of the Intestinal Immune Infiltrate and Integrin Signatures of Tissue- Resident CD8⁺ T Cells in Lynch Syndrome

Jacob Nattermann, Germany

Pre-empting Vaccine Barriers in Lynch Syndrome: Profiling Immune Evasion Across Precancerous Progression

Nicole Cianci, United Kingdom

10:10 – 10:40

Coffee/Tea Break

Laguna Ballroom

Meet-the-Expert Session:

Diving deeper into the genome with Illumina Constellation Mapped Reads

Simeen Malek, Singapore

Alvin Ng, Singapore

10:40 – 12:30

Session 4: Genetics and Molecular Insights in Hereditary Gastrointestinal Tumours 2

Chairs: Daniel Buchanan, Australia | Benjamin Zare, United Kingdom [Y-InSiGHT]

10:40 – 11:00

Adenoma-Carcinoma Model: Time to Move On

Aysel Ahadova, Germany

11:00 – 11:20

Germline Mosaicism in the Clinic: When to Suspect, How to Manage

Maartje Nielsen, Netherlands

11:20 – 12:30

Abstract Presentations 4

Chairs: Ingrid Winship, Australia | Hidewaki Nakagawa, Japan

Evidence for MLH3 as a cause for colorectal polyposis – a multinational study

Olkinuora Alisa, Switzerland

Molecular landscapes of colorectal polyps and cancers from serrated polyposis syndrome patients with germline RNF43 variants

Jihoon E. Joo, Australia

Germline pathogenic variants in homologous recombination repair pathway genes and the presence of the homologous recombination deficiency mutational signature in early-onset colorectal cancer

Daniel Buchanan, Australia

Towards prevention of replication repair deficient childhood cancers using neoantigen mRNA-LNP Vaccine

Sunam Mander, Canada

Clinical, molecular, and functional insights into POLE and POLD1 proofreading deficiency

Laura Valle, Spain

Mismatch repair deficiency in histologically normal appearing normal urothelium in Lynch syndrome carriers

Matthias Kloor, Germany

Investigating somatic and rare germline mechanisms in patients with unexplained mismatch repair deficiency

Giovana Tardin Torrezan, Brazil

12:30 – 13:50

Lunch Break

Poster Judging Session A

13:50 – 15:40

Session 5: Polyposis and Desmoid Management

Chairs: Finlay Macrae, Australia | Claudia Wu, Hong Kong SAR

13:50 – 14:10

Current Best Practices and Emerging Therapies in Desmoid Management

Susan Clark, United Kingdom

14:10 – 14:30

Role of Small Bowel Intestinal Transplantation in Surgical Management of FAP

David Liska, United States

14:30 – 15:40

Abstract Presentations 5

Chairs: Marc Greenblatt, United States | Diantha Terlouw, Netherlands [Y-InSiGHT]

Defining the Risk of Desmoid Disease Following Surgery in Familial Adenomatous Polyposis (FAP) Patients with a Low Risk Genotype

Andrew Latchford, United Kingdom

Defining The Picture of Desmoid Disease in Children and Young Adults with Familial Adenomatous Polyposis

Benjamin Zare, United Kingdom

Novel Endoscopic Classification for Duodenal Polyposis in Individuals with Familial Adenomatous Polyposis: the DRACO multi-center study

Marco Vitellaro, Italy

Clinical syndromes linked to biallelic germline variants in MCM8 and MCM9

Noah Cornelis Helderman, Netherlands

Outcomes following endoscopic versus transduodenal resection in FAP patients with duodenal adenomas: a meta-analysis

Divya L Deverakonda, United States

Comparison of desmoid disease risk after prophylactic minimally invasive versus open restorative proctocolectomy in patients with FAP

Susan Clark, United Kingdom

The role of genotoxic gut bacteria in serrated polyposis syndrome and unexplained adenomatous polyposis

Yen Lin Chu, Australia

15:40 – 16:10

Coffee/Tea Break

Albatross & Birdie

Get to Know Journal of Gastropenterology and Hepatology (JGH)

Session

Rakesh Aggarwal, Chair, Journal of Gastroenterology and Hepatology Foundation

Laguna Ballroom

Meet-the-Expert Session:

AI in Precision Medicine on AWS

Charlie Lee, Singapore

Mai Chan Lau, Singapore

16:10 – 17:40

Session 6: Polyposis Management and Pathology

Chairs: Ian Frayling, United Kingdom | M Logaswari, Singapore

16:10 – 16:30

Role of Local Excision and Organ-Preserving Strategies in Hereditary GI Cancer

Matthew Kalady, United States

(Society of Colorectal Surgeons Singapore nominated speaker)

16:30 – 16:50

Use of AI in Colorectal Cancer Pathology

Leow Wei Qiang, Singapore

(International Academy of Pathology (Singapore Division) nominated speaker)

16:50 – 17:40

Abstract Presentations 6

Chairs: Andrew Latchford, United Kingdom | Ernest Eu, Singapore

Using Oxford Nanopore Technologies long-read sequencing to resolve unexplained hereditary colorectal cancer and polyposis syndrome patients

Jihoon E. Joo, Australia

Small bowel surveillance investigations, interventions and outcomes in a large UK Peutz-Jeghers syndrome cohort

Roshani Patel, United Kingdom

Duodenal involvement in MUTYH-associated polyposis: findings from an international prospective study and implications for endoscopic surveillance

Imogen Bennett, United Kingdom

Risk of Colorectal Cancer in Li Fraumeni Syndrome

Stephen B. Gruber, United States

Molecular and clinicopathological profiling of desmoid tumours in familial adenomatous polyposis through RNA sequencing analysis

Benjamin Zare, United Kingdom

17:40 – 18:40

Poster Judging Session B

18:40 – 18:55

Day 2 Adjourn

19:30 – 22:00

Violet Oon

Council Dinner

(By invite only)

Offsite

Night Safari Tour

(Ticketed)

Main Congress Day 3

07:30 – 08:20

Albatross & Birdie

InSiGHT Asia Chapter / ICaN Meeting

Chairs:

Joanne Ngeow, Singapore

Finlay Macrae, Australia

Time

Laguna Ballroom

08:30 – 10:30

Session 7: Hereditary Gastric Cancer Surveillance and Management

Chairs: Bryson Katona, United States | Tan Yu Bin, Singapore

08:30 – 08:50

Best Practices in Gastric Cancer Care for High Risk Patients

Jean Christophe Saurin, France

(Gastroenterological Society of Singapore nominated speaker)

08:50 – 09:10

Hereditary Diffuse Gastric Cancer (HDGC): Pathological Insights and Clinical Implications

Chella van der Post, Netherlands

09:10 – 09:50

Abstract Presentations 7

Chairs: Intan Schrader, Canada | Ladan Goshayeshi, Iran

Clinical Outcomes and Management of Gastric White Mucosal Patches in Patients with Familial Adenomatous Polyposis

Carol Burke, United States

Penetrance of CDH1 Pathogenic Variants: A Multicenter Analysis from the GASTRIC Consortium

Ophir Gilad, United States

Outcomes of gastric surveillance in juvenile polyposis syndrome

Victoria Cuthill, United Kingdom

Longitudinal analysis of fundic gland cysts as predictors of gastric neoplasia in familial adenomatous polyposis

Robert Hüneburg, Germany

09:50 – 10:30

Panel Discussion

Moderator: Andrew Latchford, United Kingdom

Panellists: Evelien Dekker, Netherlands

Carol Burke, United States

10:30 – 11:00

Coffee/Tea Break

Laguna Ballroom

Meet the Expert

11:00 – 12:40

Session 8: Advances in Pancreatic Cancer Research

Chairs: Laura Valle, Spain | Chenlei Wen, China

11:00 – 11:20

Update from PRECEDE Study

Diane Simeone, United States

(Hepato Pancreato Biliary Association nominated speaker)

11:20 – 11:40

Early Onset Pancreastic Cancer in China: Contribution of Genetics

Shen Baiyong, China

11:40 – 12:40

Abstract Presentations 8

Chairs: Sharon Plon, United States | Frances Victoria F. Que, Philippines

Prevalence Of Germline Pathogenic Variants Among Pancreatic Cancer Patients in Singapore

Nur Diana Binte Ishak, Singapore

Parent-of-Origin-Aware genomic analysis Enhances the Genetic Risk Assessment in Pancreatic Ductal Adenocarcinoma

Kasmintan A Schrader, Canada

Yield of Germline Genetic Testing among Families with Pancreatic Cancer Clustering

Asaf Maoz, United States

Clinical Characteristics and Outcomes of Pancreatic Cancer Patients with Germline HRD Mutations: A Retrospective Cohort Study

Zewen Zhang, Singapore

Lynch Syndrome – Pancreatic Cancer Risk and Survival: A Nationwide Dutch Cohort Study

Monique van Leerdam, Netherlands

Gastrointestinal Cancer Risks in Israeli BRCA1/BRCA2 Mutation Carriers

Sari Lieberman, Israel

12:40 – 14:00

Lunch Break

Speakers’ Ready Room

Council Meeting

(InSiGHT Council Members Only)

Albatross & Birdie

CMMRD Workshop

Chairs:

Uri Tabori, Canada

Anirban Das, Canada

 Lucie Stengs, Canada

14:00 – 15:30

Session 9: Advances in Lynch Syndrome Research 1

Chairs: Raj Ramesar, South Africa | Mev Domínguez Valentin, Norway

14:00 – 14:20

Lynch Syndrome Screening, And Diagnosis and Management: The Chinese Experience

Ding Peirong, China

14:20 – 15:30

Abstract Presentations 9

Chairs: Raj Ramesar, South Africa | Mev Domínguez Valentin, Norway

A systematic review and meta-analysis on colorectal neoplasia detection in Lynch syndrome

Stephanie Poo, United Kingdom

Incidence And Predictors of Advanced Neoplasia In Patients with Lynch Syndrome on Surveillance Colonoscopy Performed at or after Age 65 years

Carol A. Burke, United States

Adenoma Incidence Trends by Genotype in Lynch Syndrome: A Retrospective Cohort Study of 318 MD Anderson Cancer Center Patients

Luigi Ricciardiello, United States

Impact of surveillance colonoscopy on colorectal cancer incidence and mortality in Lynch syndrome: an observational cohort study

Kevin Monahan, United Kingdom

Non-Neoplastic Precursor Lesions and Somatic Alterations in Lynch Syndrome–Associated Upper Gastrointestinal Cancers

Hugo Montemont, Germany

Potential Impact of AI-assisted Colonoscopy on Non-AI Performance in Lynch Syndrome Surveillance: Evidence of a Skill Effect

Tim Marwitz, Germany

Deep Learning Model Distinguishes Lynch Syndrome from Sporadic MSI-H using Adenoma Histology

Srividhya Sainath, Germany

15:30 – 16:00

Coffee/Tea Break

Albatross & Birdie

Get to Know Familial Cancer Session

Gabriel Capellá, Editors-in-Chief, Familial Cancer

Hans Vasen, Editors-in-Chief, Familial Cancer

Laguna Ballroom

Meet-the-Expert Session:

Reveal more cancer biology with ultra-rich Oxford Nanopore sequencing data

Manop Pithukpakorn, Thailand

Lei Tong, Singapore

16:00 – 17:40

Session 10: Advances in Lynch Syndrome Research 2

Chairs: Maria Katapodi, Switzerland | Rakefet Shtoyerman, Israel

16:00 – 16:20

Implementing Population Genomics for Hereditary GI Cancer Prevention: Lessons from PROTECT

Ranjit Manchanda, United Kingdom

16:20 – 17:40

Abstract Presentations 10

Chairs: Maria Katapodi, Switzerland | Rakefet Shtoyerman, Israel

Cancer risks in first-degree relatives of individuals with biallelic somatic DNA mismatch repair mutations

Romy Walker, Australia

A multiplex assay of variant effect (MAVE) of MSH6 enables accurate, prospective Lynch Syndrome clinical variant interpretation

Anthony Scott, United States

Reassessing MSH6 variants in ClinVar using MMR-specific ACMG/AMP guidelines and recent literature

Hashini Kristhorubaduge, Australia

Immunogenic frameshift mutations in patients with Lynch syndrome and immune suppression programs supporting colorectal cancer development

Aimee L. Lucas, United States

Prospective Evaluation of a Blood-Based Digital PCR MSI Assay for Early Colorectal Cancer Detection in Lynch Syndrome Carriers: the BioLynch Study

Mattia Boeri, Italy

Blood-based T cell clonal expansion as a biomarker of mismatch repair-deficient tumours in Lynch syndrome

Penelope Edwards, United Kingdom

Mapping the T Cell Receptor Repertoire in Lynch Syndrome-Associated Colorectal Cancer

Penelope Edwards, United Kingdom

Neoantigen-loaded dendritic cell vaccine for cancer prevention in Lynch Syndrome: Early results from a phase Ib clinical trial

Joaquín Castillo-Iturra, Spain

17:40 – 18:20

InSiGHT General Meeting 

18:20 – 18:35

Day 3 Adjourn

19:00

Onwards

Hopscotch (Gardens By The Bay)

Congress Dinner

Main Congress Day 4

08:00 – 08:50

Laguna Ballroom

EOCRC Hour

Chairs:

Daniel Buchanan, Australia

Alvin Ng, Singapore

Albatross & Birdie

Collab Lab @ InSiGHT

Chair:

Joanne Ngeow, Singapore

Time

Laguna Ballroom

09:00 – 09:15

Address by Guest of Honour

Koh Poh Koon, Senior Minister of State for Health and Manpower, Singapore

09:15 – 10:45

Session 11: Best Oral Communications

Chairs: Francesc Balaguer, Spain | Romy Walker, Australia

09:15 – 10:45

Best Oral Communications

Chairs: Francesc Balaguer, Spain | Romy Walker, Australia

The Newcastle MSI-Plus Assay for Low Cost and Scalable Lynch Syndrome Screening of Cancer Patients and Urine-based Early Detection of Lynch Syndrome Urothelial Cancer

Richard Gallon, United Kingdom

TA-Repeat Expansions Drive WRN Dependency and Guide Inhibitor Therapy in Sporadic and Lynch-Associated MSI Cancers

Gabriele Picco, United Kingdom

Comparison of Postoperative Morbidity Following Total Colectomy with Ileorectal Anastomosis vs Proctocolectomy with Ileal Pouch-anal Anastomosis in Familial Adenomatous Polyposis

Jared R Hendren, United States

Cap-assisted vs. side-viewing duodenoscopy for papilla visualization in familial adenomatous polyposis: a randomized blinded cross-over trial (CAPFAP)

Robert Hüneburg, Germany

Pancreatic Cancer Surveillance Not Recommended for Familial Adenomatous Polyposis: A Fine And Gray Risk Analysis

Monique van Leerdam, Netherlands

Systemic Markers for Predicting and Monitoring Response to Immune Checkpoint Blockade Therapy in Patients with Advanced Microsatellite-unstable Gastrointestinal Cancers: A Pilot Study

Aysel Ahadova, Germany

10:45 – 11:15

Coffee/Tea Break

11:15 – 12:35

Session 12: Frontiers in Lynch Syndrome Research

Chairs: Kevin Monahan, United Kingdom | Rebecca Caeser, Singapore

11:15 – 11:35

Lynch Syndrome in Singapore: Insights Into The Local Landscape

Joanne Ngeow, Singapore

11:35 – 11:55

Cancer Vaccines in Lynch Syndrome – Progress and Promise

David Church, United Kingdom

(Singapore Society of Oncology nominated speaker)

11:55 – 12:15

Cancer Prevention with Aspirin: CaPP3 and Beyond

Sir John Burn, United Kingdom

12:15 – 12:35

From Evidence to Practice: Updates on Lynch Sydrome Guidelines

Giulia Martina Cavestro, Italy

12:35 – 12:55

Concluding Remarks

Lunch will not be provided. We encourage delegates to make their own dining arrangements.

13:00 – 16:00

Albatross & Birdie

Living with Lynch Patient Conference

(By Invite Only)